Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 236
interventional 216
Observational 19
Registry 1

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 79
Drug|Other 23
Biological 15
Drug|Radiation 15
Biological|Drug 13
Drug|Procedure 13
Radiation 6
Biological|Drug|Other 5
Drug|Other|Radiation 5
Drug|Other|Procedure 4
Biological|Other 3
Biological|Other|Procedure 3
Drug|Procedure|Radiation 3
Other 3
Biological|Drug|Other|Procedure 2
Biological|Drug|Procedure 2
Biological|Procedure|Radiation 2
Device 2
Device|Drug 2
Device|Drug|Procedure 2
Drug|placebo 2
Procedure 2
Behavioral 1
Biological|Drug|Radiation 1
Biological|Procedure 1
Combination Product 1
Device|Other|Procedure 1
Drug|Genetic|Other|Procedure 1
Drug|Other|Procedure|Radiation 1
Drug|placebo|Procedure 1
Other|Procedure|Radiation 1
Procedure|Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 163
United States|Canada 8
NA 7
France 4
China 3
Germany 3
United States|Australia|Canada 2
Australia 1
Austria|France|Germany|Netherlands|Switzerland 1
Austria|Georgia|Germany|India|Israel|Russian Federation 1
Canada 1
Finland 1
France|United States|Australia|Canada|Italy|United Kingdom 1
Germany|Switzerland 1
Iran, Islamic Republic of 1
Italy 1
Korea, Republic of 1
Netherlands 1
Serbia 1
Switzerland 1
Turkey 1
United States|Argentina|Australia|Belgium|Brazil|Canada|Czechia|Denmark|Finland|France|Germany|Israel|Italy|Japan|Netherlands|Russian Federation|Spain|Sweden|Switzerland|United Kingdom 1
United States|Australia 1
United States|Australia|Belgium|Canada|Germany|Italy|Netherlands|Poland|Russian Federation|United Kingdom 1
United States|Australia|Canada|Netherlands|New Zealand|Puerto Rico|Switzerland 1
United States|Australia|Canada|Netherlands|New Zealand|Switzerland 1
United States|Australia|Canada|New Zealand 1
United States|Australia|Canada|New Zealand|Puerto Rico 1
United States|Belgium|Canada|France|Germany|Italy|Netherlands|United Kingdom 1
United States|France|Spain 1
United States|Germany|Israel 1
United States|Puerto Rico 1
United States|Switzerland 1

Sites per Study

Site_count Study_Count
1 120
2 17
3 5
4 10
5 3
6 6
7 5
8 6
9 2
10 4
11 4
12 6
13 1
14 1
17 4
18 1
19 1
20 1
23 2
24 2
26 1
36 1
42 1
69 1
92 1
96 1
101 1
103 1
126 1
137 1
152 1
180 1
204 1
230 1
308 1

Phase

Phase Study_Count
Phase 1 93
Phase 2 64
Phase 1/Phase 2 27
Phase 3 15
Early Phase 1 8
N/A 7
Phase 2/Phase 3 1
Phase 4 1

Number of Arms

Number_of_Arms Count_of_Studies
1 117
2 54
3 14
4 7
5 2
6 1
7 1
NA 20

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 5.0 36.0 6.00000 11.00000 1.00000 101 62.0000 250
1st Qu. 11.5 38.0 16.50000 31.50000 26.50000 101 162.7500 250
Median 14.5 44.0 24.00000 61.00000 41.00000 101 235.0000 250
Mean 32.5 77.0 31.11957 64.23077 56.95312 101 271.2857 250
3rd Qu. 25.5 68.5 39.25000 74.25000 81.50000 101 334.5000 250
Max. 150.0 246.0 108.00000 180.00000 181.00000 101 712.0000 250

Trial Group Type

group_type Group_Count
Experimental 282
Active Comparator 26
NA 20
Other 7
Placebo Comparator 3

Intervention Model

intervention_model Study_Count
Single Group Assignment 140
Parallel Assignment 58
Sequential Assignment 10
NA 7
Crossover Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 205
Diagnostic 4
Supportive Care 3
Basic Science 2
Other 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 8
NA 3
Netherlands 2
United States|Canada 2
China 1
Germany 1
Lithuania 1
United States|Australia|Canada|New Zealand|Puerto Rico|Switzerland 1

Sites per Study

Site_count Study_Count
1 13
4 1
5 1
6 1
41 1
66 1
187 1

Enrollment Metrics

Measure Observational
Min 8.0000
1st Qu 67.0000
Median 105.0000
Mean 490.4211
3rd Qu 485.5000
Max 3050.0000

Observation Model

observational_model Study_Count
Cohort 8
Case-Only 5
NA 3
Case-Control 2
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 15
NA 3
Retrospective 1

Registries

Studies by Country

Country Study_Count
United States 1

Sites per Study

Site_count Study_Count
8 1

Enrollment Metrics

Measure Registries
Min 570
1st Qu 570
Median 570
Mean 570
3rd Qu 570
Max 570

Registry Model

observational_model Study_Count
Cohort 1

Time Perspective

time_perspective Study_Count
Prospective 1

Follow-up

target_duration Study_Count
2 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04430842 Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S https://ClinicalTrials.gov/show/NCT04430842 Recruiting Quadriga Biosciences, Inc. 2021-09-30
NCT04166409 A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma https://ClinicalTrials.gov/show/NCT04166409 Recruiting National Cancer Institute (NCI) 2026-12-31
NCT03919071 Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma https://ClinicalTrials.gov/show/NCT03919071 Recruiting National Cancer Institute (NCI) 2022-06-01
NCT03355794 A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) https://ClinicalTrials.gov/show/NCT03355794 Active, not recruiting Children’s Hospital Medical Center, Cincinnati 2020-07-01
NCT03332355 Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2 https://ClinicalTrials.gov/show/NCT03332355 Recruiting Vanquish Oncology, Inc. 2019-12-30
NCT03243461 International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) https://ClinicalTrials.gov/show/NCT03243461 Recruiting University of Göttingen 2022-01-01
NCT03224104 Study of TG02 in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma https://ClinicalTrials.gov/show/NCT03224104 Recruiting European Organisation for Research and Treatment of Cancer - EORTC 2020-08-31
NCT03180502 Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma https://ClinicalTrials.gov/show/NCT03180502 Recruiting NRG Oncology 2025-01-31
NCT03152318 A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 https://ClinicalTrials.gov/show/NCT03152318 Recruiting Dana-Farber Cancer Institute 2021-07-31
NCT03072134 Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma https://ClinicalTrials.gov/show/NCT03072134 Completed Northwestern University 2020-04-06
NCT03043391 Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children https://ClinicalTrials.gov/show/NCT03043391 Recruiting Istari Oncology, Inc. 2020-07-01
NCT03032484 TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma https://ClinicalTrials.gov/show/NCT03032484 Active, not recruiting The University of Texas Health Science Center at San Antonio 2021-04-10
NCT03027388 Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma https://ClinicalTrials.gov/show/NCT03027388 Recruiting National Institutes of Health Clinical Center (CC) 2021-08-30
NCT03022578 Laser Interstitial Thermal Therapy and Lomustine in Treating Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma https://ClinicalTrials.gov/show/NCT03022578 Recruiting M.D. Anderson Cancer Center 2021-11-01
NCT03020602 BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab https://ClinicalTrials.gov/show/NCT03020602 Active, not recruiting Stanford University 2019-04-04
NCT02924038 A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG) https://ClinicalTrials.gov/show/NCT02924038 Recruiting University of California, San Francisco 2021-06-30
NCT02903784 Neural Basis of Language Processing https://ClinicalTrials.gov/show/NCT02903784 Completed University Hospital, Montpellier 2015-02-28
NCT02885324 Pilot Study of Cabozantinib for Recurrent or Progressive High-Grade Glioma in Children https://ClinicalTrials.gov/show/NCT02885324 Recruiting Indiana University 2021-07-31
NCT02858895 Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma https://ClinicalTrials.gov/show/NCT02858895 Completed Medicenna Therapeutics, Inc. 2019-09-12
NCT02796261 Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients https://ClinicalTrials.gov/show/NCT02796261 Recruiting Orbus Therapeutics, Inc. 2020-06-30
NCT02766699 A Study to Evaluate the Safety, Tolerability and Immunogenicity of EGFR(V)-EDV-Dox in Subjects With Recurrent Glioblastoma Multiforme (GBM) https://ClinicalTrials.gov/show/NCT02766699 Recruiting Engeneic Pty Limited 2019-12-31
NCT02758366 Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma https://ClinicalTrials.gov/show/NCT02758366 Recruiting Meyer Children’s Hospital 2020-07-31
NCT02722512 Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine https://ClinicalTrials.gov/show/NCT02722512 Recruiting Ann & Robert H Lurie Children’s Hospital of Chicago 2019-05-31
NCT02644291 Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors https://ClinicalTrials.gov/show/NCT02644291 Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2021-06-30
NCT02629757 A Study on β-elemene as Maintain Treatment for Newly Diagnosed Malignant Gliomas https://ClinicalTrials.gov/show/NCT02629757 Recruiting Sun Yat-sen University 2020-04-30
NCT01331135 Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors https://ClinicalTrials.gov/show/NCT01331135 Completed Emory University 2017-08-09
NCT02942264 Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma https://ClinicalTrials.gov/show/NCT02942264 Recruiting National Institutes of Health Clinical Center (CC) 2021-08-02
NCT02023905 Everolimus With and Without Temozolomide in Adult Low Grade Glioma https://ClinicalTrials.gov/show/NCT02023905 Active, not recruiting University of California, San Francisco 2021-09-30
NCT01189266 Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma https://ClinicalTrials.gov/show/NCT01189266 Active, not recruiting National Cancer Institute (NCI) 2017-06-30
NCT03389802 Phase I Study of APX005M in Pediatric CNS Tumors https://ClinicalTrials.gov/show/NCT03389802 Recruiting Pediatric Brain Tumor Consortium 2020-09-30
NCT02529072 Nivolumab With DC Vaccines for Recurrent Brain Tumors https://ClinicalTrials.gov/show/NCT02529072 Completed Duke University 2017-09-15
NCT02490930 A Safety Study of Fingolimod With Radiation and Temozolomide in Newly Diagnosed High Grade Glioma https://ClinicalTrials.gov/show/NCT02490930 Completed Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2017-09-30
NCT02444546 Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors https://ClinicalTrials.gov/show/NCT02444546 Active, not recruiting Mayo Clinic 2018-07-13
NCT02372409 Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors https://ClinicalTrials.gov/show/NCT02372409 Recruiting Washington University School of Medicine 2021-10-30
NCT02366728 DC Migration Study for Newly-Diagnosed GBM https://ClinicalTrials.gov/show/NCT02366728 Active, not recruiting Duke University 2020-08-31
NCT02343224 Pegylated Interferon ALFA-2b in Children With Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas https://ClinicalTrials.gov/show/NCT02343224 Recruiting Emory University 2021-12-31
NCT02209428 A Prospective Cohort to Study the Effect of Temozolomide on IDH Mutational Low Grade Gliomas https://ClinicalTrials.gov/show/NCT02209428 Active, not recruiting Huashan Hospital 2019-04-30
NCT02192359 Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas https://ClinicalTrials.gov/show/NCT02192359 Recruiting City of Hope Medical Center 2021-03-07
NCT02186509 Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas https://ClinicalTrials.gov/show/NCT02186509 Completed Thomas Jefferson University 2017-03-31
NCT02101905 Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma https://ClinicalTrials.gov/show/NCT02101905 Active, not recruiting National Cancer Institute (NCI) 2019-12-31
NCT02077543 Multicenter Safety Trial Assessing an Innovative Tumor Molecular and Cellular Print Medical Device in Glioma https://ClinicalTrials.gov/show/NCT02077543 Recruiting University Hospital, Grenoble 2020-06-30
NCT02062827 Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma https://ClinicalTrials.gov/show/NCT02062827 Recruiting University of Alabama at Birmingham 2021-09-30
NCT01316809 AZD8055 for Adults With Recurrent Gliomas https://ClinicalTrials.gov/show/NCT01316809 Completed National Institutes of Health Clinical Center (CC) 2014-04-14
NCT01290692 Study To Test the Safety and Efficacy of TVI-Brain-1 As A Treatment for Recurrent Grade IV Glioma https://ClinicalTrials.gov/show/NCT01290692 Completed TVAX Biomedical 2013-12-31
NCT01288235 Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation https://ClinicalTrials.gov/show/NCT01288235 Active, not recruiting Massachusetts General Hospital 2022-09-30
NCT01269853 Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA https://ClinicalTrials.gov/show/NCT01269853 Recruiting Northwell Health 2020-10-31
NCT02015819 Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas https://ClinicalTrials.gov/show/NCT02015819 Active, not recruiting City of Hope Medical Center 2019-06-30
NCT02010606 Phase I Study of a Dendritic Cell Vaccine for Patients With Either Newly Diagnosed or Recurrent Glioblastoma https://ClinicalTrials.gov/show/NCT02010606 Active, not recruiting Cedars-Sinai Medical Center 2020-10-31
NCT01999270 Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors https://ClinicalTrials.gov/show/NCT01999270 Completed Washington University School of Medicine 2016-05-31
NCT01985256 Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor https://ClinicalTrials.gov/show/NCT01985256 Completed Tocagen Inc. 2016-03-03
NCT01975116 p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors https://ClinicalTrials.gov/show/NCT01975116 Completed Pediatric Brain Tumor Consortium 2015-04-30
NCT01967758 Phase I Study of Safety and Immunogenicity of ADU-623 https://ClinicalTrials.gov/show/NCT01967758 Completed Providence Health & Services 2018-06-18
NCT01922076 Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas https://ClinicalTrials.gov/show/NCT01922076 Active, not recruiting National Cancer Institute (NCI) 2021-10-31
NCT01884740 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 https://ClinicalTrials.gov/show/NCT01884740 Recruiting Weill Medical College of Cornell University 2025-01-31
NCT01837862 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas https://ClinicalTrials.gov/show/NCT01837862 Recruiting Northwell Health 2020-04-30
NCT01833273 Dose Evaluation Safety STudy IN Individuals With Astrocytoma Taking PolyMVA https://ClinicalTrials.gov/show/NCT01833273 Completed Stony Brook University 2013-10-31
NCT01808820 Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma https://ClinicalTrials.gov/show/NCT01808820 Active, not recruiting University of Miami 2018-11-02
NCT01700569 Phase-1 Study of Folinic Acid to Modulate MGMT Gene in Glioblastoma https://ClinicalTrials.gov/show/NCT01700569 Recruiting Institut Cancerologie de l’Ouest 2020-09-30
NCT01663012 Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma https://ClinicalTrials.gov/show/NCT01663012 Completed Stanford University 2015-02-28
NCT01649830 Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma https://ClinicalTrials.gov/show/NCT01649830 Recruiting Sun Yat-sen University 2025-08-31
NCT01648348 Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme https://ClinicalTrials.gov/show/NCT01648348 Completed National Cancer Institute (NCI) 2016-05-11
NCT01644955 Carboplatin in Treating Patients With Recurrent High-Grade Gliomas https://ClinicalTrials.gov/show/NCT01644955 Completed Ohio State University Comprehensive Cancer Center 2017-12-08
NCT01553149 Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma https://ClinicalTrials.gov/show/NCT01553149 Active, not recruiting National Cancer Institute (NCI) 2020-06-30
NCT01522820 Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors https://ClinicalTrials.gov/show/NCT01522820 Completed Roswell Park Cancer Institute 2016-07-31
NCT01514201 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas https://ClinicalTrials.gov/show/NCT01514201 Completed National Cancer Institute (NCI) 2018-03-28
NCT01502241 Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly https://ClinicalTrials.gov/show/NCT01502241 Completed Heidelberg University 2010-11-30
NCT01475006 AMG 595 First-in-Human in Recurrent Gliomas https://ClinicalTrials.gov/show/NCT01475006 Completed Amgen 2016-04-30
NCT01470794 Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor https://ClinicalTrials.gov/show/NCT01470794 Completed Tocagen Inc. 2016-04-12
NCT01462695 Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma https://ClinicalTrials.gov/show/NCT01462695 Completed National Cancer Institute (NCI) 2013-12-31
NCT01392209 Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma https://ClinicalTrials.gov/show/NCT01392209 Completed Memorial Sloan Kettering Cancer Center 2019-11-15
NCT01380782 BIBF 1120 for Recurrent High-Grade Gliomas https://ClinicalTrials.gov/show/NCT01380782 Completed Dana-Farber Cancer Institute 2013-07-31
NCT04295759 INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas https://ClinicalTrials.gov/show/NCT04295759 Recruiting Pediatric Brain Tumor Consortium 2022-03-31
NCT04197934 WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases https://ClinicalTrials.gov/show/NCT04197934 Recruiting Mayo Clinic 2022-12-20
NCT04135807 Implantable Microdevice In Primary Brain Tumors https://ClinicalTrials.gov/show/NCT04135807 Recruiting Dana-Farber Cancer Institute 2021-01-21
NCT04065776 Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma https://ClinicalTrials.gov/show/NCT04065776 Recruiting St. Jude Children’s Research Hospital 2023-05-31
NCT03975829 Pediatric Long-Term Follow-up and Rollover Study https://ClinicalTrials.gov/show/NCT03975829 Recruiting Novartis 2022-12-23
NCT03956706 Study of Stereotactic Radiosurgery to the Subventricular Zone in Malignant Gliomas https://ClinicalTrials.gov/show/NCT03956706 Recruiting Northwell Health 2021-06-30
NCT03896568 Oncolytic Adenovirus DNX-2401 in Treating Patients With Recurrent High-Grade Glioma https://ClinicalTrials.gov/show/NCT03896568 Recruiting M.D. Anderson Cancer Center 2020-02-28
NCT03893487 Fimepinostat in Treating Brain Tumors in Children and Young Adults https://ClinicalTrials.gov/show/NCT03893487 Recruiting University of California, San Francisco 2022-06-01
NCT03796273 Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases https://ClinicalTrials.gov/show/NCT03796273 Recruiting Wake Forest University Health Sciences 2021-02-01
NCT03739372 Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma https://ClinicalTrials.gov/show/NCT03739372 Recruiting University of California, San Francisco 2020-11-01
NCT03657576 Trial of C134 in Patients With Recurrent GBM https://ClinicalTrials.gov/show/NCT03657576 Recruiting University of Alabama at Birmingham 2022-09-30
NCT03633552 Efficacy of Two Temozolomide Regimens in Adjuvant Treatment of Patients With Brain High Grade Glioma https://ClinicalTrials.gov/show/NCT03633552 Recruiting Mashhad University of Medical Sciences 2021-03-03
NCT03603405 HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM https://ClinicalTrials.gov/show/NCT03603405 Recruiting The Methodist Hospital System 2023-12-31
NCT03596086 HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM https://ClinicalTrials.gov/show/NCT03596086 Recruiting The Methodist Hospital System 2023-12-30
NCT03581292 Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations https://ClinicalTrials.gov/show/NCT03581292 Recruiting National Cancer Institute (NCI) 2024-10-29
NCT03528642 CB-839 With Radiation Therapy and Temozolomide in Treating Participants With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma https://ClinicalTrials.gov/show/NCT03528642 Recruiting National Cancer Institute (NCI) 2022-12-05
NCT03450850 Study Of NOVOTTF-200A In Bevacizumab-Naive Subjects With Recurrent Grade III Malignant Astrocytoma https://ClinicalTrials.gov/show/NCT03450850 Recruiting University of California, Irvine 2023-06-30
NCT03434262 SJDAWN: St. Jude Children’s Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors https://ClinicalTrials.gov/show/NCT03434262 Recruiting St. Jude Children’s Research Hospital 2025-02-28
NCT01250470 Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma https://ClinicalTrials.gov/show/NCT01250470 Completed Roswell Park Cancer Institute 2014-05-29
NCT01240460 Exploratory Study of XL765 (SAR245409) or XL147 (SAR245408) in Subjects With Recurrent Glioblastoma Who Are Candidates for Surgical Resection https://ClinicalTrials.gov/show/NCT01240460 Completed Sanofi 2012-06-30
NCT01238237 Super-Selective Intraarterial Cerebral Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory GBM and AA https://ClinicalTrials.gov/show/NCT01238237 Completed Northwell Health 2016-01-31
NCT01236560 Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma https://ClinicalTrials.gov/show/NCT01236560 Active, not recruiting National Cancer Institute (NCI) 2016-09-27
NCT01234740 Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases https://ClinicalTrials.gov/show/NCT01234740 Completed City of Hope Medical Center 2013-03-31
NCT01222754 Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas https://ClinicalTrials.gov/show/NCT01222754 Completed National Institutes of Health Clinical Center (CC) 2019-04-17
NCT01204684 Dendritic Cell Vaccine for Patients With Brain Tumors https://ClinicalTrials.gov/show/NCT01204684 Active, not recruiting Jonsson Comprehensive Cancer Center 2021-01-31
NCT01180816 Super-Selective Intraarterial Cerebral Infusion Of Temozolomide (Temodar) For Treatment Of Newly Diagnosed GBM And AA https://ClinicalTrials.gov/show/NCT01180816 Active, not recruiting Northwell Health 2017-12-31
NCT01171469 Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor https://ClinicalTrials.gov/show/NCT01171469 Completed Masonic Cancer Center, University of Minnesota 2012-05-31
NCT01165632 Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma https://ClinicalTrials.gov/show/NCT01165632 Active, not recruiting Mayo Clinic 2013-11-01
NCT01156584 A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma https://ClinicalTrials.gov/show/NCT01156584 Completed Tocagen Inc. 2016-08-18
NCT01151670 Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain Tumors https://ClinicalTrials.gov/show/NCT01151670 Completed Wake Forest University Health Sciences 2014-08-31
NCT01144247 Cellular Immunotherapy Study for Brain Cancer https://ClinicalTrials.gov/show/NCT01144247 Completed Jonsson Comprehensive Cancer Center 2015-07-31
NCT01131234 Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors https://ClinicalTrials.gov/show/NCT01131234 Completed National Cancer Institute (NCI) 2014-09-30
NCT01125800 A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB https://ClinicalTrials.gov/show/NCT01125800 Completed Novartis 2014-10-31
NCT01119599 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma https://ClinicalTrials.gov/show/NCT01119599 Completed National Cancer Institute (NCI) 2013-06-30
NCT01089101 Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma https://ClinicalTrials.gov/show/NCT01089101 Recruiting National Cancer Institute (NCI) 2022-12-31
NCT01082926 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 https://ClinicalTrials.gov/show/NCT01082926 Completed City of Hope Medical Center 2013-09-30
NCT01081223 Phase I/II Study To Test The Safety and Efficacy of TVI-Brain-1 As A Treatment For Recurrent Grade IV Glioma https://ClinicalTrials.gov/show/NCT01081223 Completed TVAX Biomedical 2011-03-31
NCT01076530 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors https://ClinicalTrials.gov/show/NCT01076530 Completed National Cancer Institute (NCI) 2012-10-31
NCT01068782 Study of Multiple Doses and Regimens of XL184 (Cabozantinib) in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse https://ClinicalTrials.gov/show/NCT01068782 Completed Exelixis 2011-05-31
NCT01024907 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas https://ClinicalTrials.gov/show/NCT01024907 Completed Abramson Cancer Center of the University of Pennsylvania 2014-02-28
NCT01012609 External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas https://ClinicalTrials.gov/show/NCT01012609 Active, not recruiting Memorial Sloan Kettering Cancer Center 2020-11-30
NCT00995007 A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas https://ClinicalTrials.gov/show/NCT00995007 Completed National Institutes of Health Clinical Center (CC) 2015-06-30
NCT00994500 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma https://ClinicalTrials.gov/show/NCT00994500 Completed National Cancer Institute (NCI) 2011-07-31
NCT00994071 A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors https://ClinicalTrials.gov/show/NCT00994071 Completed National Institutes of Health Clinical Center (CC) NA
NCT00968240 Super-Selective Intraarterial Intracranial Infusion of Avastin (Bevacizumab) https://ClinicalTrials.gov/show/NCT00968240 Completed Northwell Health 2014-01-31
NCT00946335 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors https://ClinicalTrials.gov/show/NCT00946335 Completed National Cancer Institute (NCI) 2011-10-31
NCT00921167 A Study to Evaluate the Efficacy of Bevacizumab Plus Irinotecan in Recurrent Gliomas https://ClinicalTrials.gov/show/NCT00921167 Completed Clinical Research Center for Solid Tumor, Korea 2012-06-30
NCT00884416 Sorafenib in Newly Diagnosed High Grade Glioma https://ClinicalTrials.gov/show/NCT00884416 Completed University Hospital, Geneva 2011-12-31
NCT00879437 Valproic Acid and Radiation Followed by Maintenance Valproic Acid and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma https://ClinicalTrials.gov/show/NCT00879437 Active, not recruiting Baylor College of Medicine 2020-06-30
NCT00874861 HLA-A2-Restricted Glioma Antigen-Peptides Vaccinations With Poly-ICLC for Recurrent WHO Grade II Gliomas https://ClinicalTrials.gov/show/NCT00874861 Completed University of Pittsburgh 2012-05-31
NCT00841555 Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Anaplastic Astrocytoma https://ClinicalTrials.gov/show/NCT00841555 Completed Ohio State University Comprehensive Cancer Center 2013-02-13
NCT03861299 The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients. https://ClinicalTrials.gov/show/NCT03861299 Recruiting Erasmus Medical Center 2023-03-06
NCT03538587 Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers https://ClinicalTrials.gov/show/NCT03538587 Recruiting National Institutes of Health Clinical Center (CC) 2021-04-01
NCT02465268 Vaccine Therapy for the Treatment of Newly Diagnosed Glioblastoma Multiforme https://ClinicalTrials.gov/show/NCT02465268 Recruiting Immunomic Therapeutics, Inc. 2023-06-30
NCT00823797 Bendamustine Hydrochloride in Treating Patients With Recurrent or Progressive Anaplastic Glioma https://ClinicalTrials.gov/show/NCT00823797 Completed University of Washington 2015-12-31
NCT00823459 Everolimus in Treating Patients With Recurrent Low-Grade Glioma https://ClinicalTrials.gov/show/NCT00823459 Completed University of California, San Francisco 2017-06-12
NCT02684058 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG https://ClinicalTrials.gov/show/NCT02684058 Recruiting Novartis 2021-11-11
NCT01172964 A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas https://ClinicalTrials.gov/show/NCT01172964 Completed City of Hope Medical Center 2015-02-11
NCT01403610 Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab https://ClinicalTrials.gov/show/NCT01403610 Completed The University of Texas Health Science Center at San Antonio 2015-10-31
NCT03911388 HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors https://ClinicalTrials.gov/show/NCT03911388 Recruiting University of Alabama at Birmingham 2023-09-01
NCT02709226 Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma https://ClinicalTrials.gov/show/NCT02709226 Recruiting National Institutes of Health Clinical Center (CC) 2020-10-30
NCT02549833 Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma https://ClinicalTrials.gov/show/NCT02549833 Recruiting University of California, San Francisco 2023-06-01
NCT02457845 HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors https://ClinicalTrials.gov/show/NCT02457845 Recruiting University of Alabama at Birmingham 2020-10-31
NCT02800486 Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA https://ClinicalTrials.gov/show/NCT02800486 Recruiting Northwell Health 2021-05-31
NCT03973918 Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG https://ClinicalTrials.gov/show/NCT03973918 Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2022-07-31
NCT03971734 Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas https://ClinicalTrials.gov/show/NCT03971734 Active, not recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2022-03-31
NCT02238496 Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas https://ClinicalTrials.gov/show/NCT02238496 Active, not recruiting Columbia University 2017-10-27
NCT03722355 Hyperfractionated RT With BCNU Versus Conventional RT With BCNU for Supratentorial Malignant Glioma https://ClinicalTrials.gov/show/NCT03722355 Completed Radiation Therapy Oncology Group 1994-03-15
NCT00789828 Efficacy and Safety of Everolimus (RAD001) in Patients of All Ages With Subependymal Giant Cell Astrocytoma Associated With Tuberous Sclerosis Complex (TSC)(EXIST-1) https://ClinicalTrials.gov/show/NCT00789828 Completed Novartis 2011-03-31
NCT00783393 SCH 52365 Phase II Clinical Study: A Study on the Efficacy and Safety of Monotherapy With SCH 52365 in Patients With First Relapsed Anaplastic Astrocytoma (Study P03745) https://ClinicalTrials.gov/show/NCT00783393 Completed Merck Sharp & Dohme Corp. 2005-06-17
NCT00782626 Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomas https://ClinicalTrials.gov/show/NCT00782626 Completed Dana-Farber Cancer Institute 2012-08-31
NCT00751270 Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant Gliomas https://ClinicalTrials.gov/show/NCT00751270 Completed Advantagene, Inc. 2010-01-31
NCT00734682 A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas https://ClinicalTrials.gov/show/NCT00734682 Completed University of California, San Francisco 2014-12-31
NCT00717210 Randomized Phase III Study of Sequential Radiochemotherapy of Anaplastic Glioma With PCV or Temozolomide https://ClinicalTrials.gov/show/NCT00717210 Completed Neuro-Oncology Working Group of the German Cancer Society 2005-02-28
NCT00679354 Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy https://ClinicalTrials.gov/show/NCT00679354 Completed National Cancer Institute (NCI) 2010-10-31
NCT00667394 Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors https://ClinicalTrials.gov/show/NCT00667394 Completed National Institutes of Health Clinical Center (CC) 2011-07-31
NCT00650923 Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma https://ClinicalTrials.gov/show/NCT00650923 Completed National Cancer Institute (NCI) 2013-06-30
NCT00638898 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor https://ClinicalTrials.gov/show/NCT00638898 Active, not recruiting City of Hope Medical Center 2020-09-01
NCT00624728 Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP) https://ClinicalTrials.gov/show/NCT00624728 Completed University Hospital, Bordeaux 2011-11-30
NCT00612651 PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas https://ClinicalTrials.gov/show/NCT00612651 Completed Duke University 2009-01-31
NCT00610571 Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas https://ClinicalTrials.gov/show/NCT00610571 Completed Duke University 2009-09-30
NCT00606008 A Phase II Trial of Sutent (Sunitinib; SU011248) for Recurrent Anaplastic Astrocytoma and Glioblastoma https://ClinicalTrials.gov/show/NCT00606008 Completed H. Lee Moffitt Cancer Center and Research Institute 2012-08-31
NCT00589875 Phase 2a Study of AdV-tk With Standard Radiation Therapy for Malignant Glioma (BrTK02) https://ClinicalTrials.gov/show/NCT00589875 Completed Advantagene, Inc. 2015-12-31
NCT00575887 Efficacy of Protracted Temozolomide in Patients With Progressive High Grade Glioma https://ClinicalTrials.gov/show/NCT00575887 Completed Marmara University 2009-03-31
NCT00499473 Sunitinib in Treating Patients With Recurrent Malignant Gliomas https://ClinicalTrials.gov/show/NCT00499473 Completed National Cancer Institute (NCI) 2009-06-30
NCT00492089 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer https://ClinicalTrials.gov/show/NCT00492089 Completed National Cancer Institute (NCI) 2010-08-31
NCT00019578 Stereotactic Radiosurgery in Treating Patients With Brain Tumors https://ClinicalTrials.gov/show/NCT00019578 Completed National Institutes of Health Clinical Center (CC) NA
NCT00431561 Phase IIb Clinical Trial With TGF-β2 Antisense Compound AP 12009 for Recurrent or Refractory High-grade Glioma https://ClinicalTrials.gov/show/NCT00431561 Completed Isarna Therapeutics GmbH 2009-03-31
NCT00430911 Radiotherapy for Malignant Astrocytomas in the Elderly https://ClinicalTrials.gov/show/NCT00430911 Completed Assistance Publique - Hôpitaux de Paris NA
NCT00411619 Everolimus (RAD001) Therapy of Giant Cell Astrocytoma in Patients With Tuberous Sclerosis Complex https://ClinicalTrials.gov/show/NCT00411619 Completed Children’s Hospital Medical Center, Cincinnati 2014-01-31
NCT00409214 Phase IIa Safety and Light Dose-escalation Study in Patients With Primary or Recurrent/High-grade Glioma Using the Litxâ„¢ System to Confirm the Zone of Tumor Destruction During the Intraoperative Treatment of Glioma https://ClinicalTrials.gov/show/NCT00409214 Completed Light Sciences Oncology 2008-02-29
NCT00392171 The Effects of Continuous 28-day (28/28) Temozolomide Chemotherapy in Subjects With Recurrent Malignant Glioma Who Have Failed the Conventional 5-day (5/28) Treatment (P04601) https://ClinicalTrials.gov/show/NCT00392171 Completed Merck Sharp & Dohme Corp. 2009-09-15
NCT00390299 Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme https://ClinicalTrials.gov/show/NCT00390299 Completed Mayo Clinic 2018-11-29
NCT00381797 Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma https://ClinicalTrials.gov/show/NCT00381797 Completed National Cancer Institute (NCI) 2015-10-31
NCT00369590 VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide https://ClinicalTrials.gov/show/NCT00369590 Completed National Cancer Institute (NCI) 2011-12-31
NCT00363272 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma https://ClinicalTrials.gov/show/NCT00363272 Completed National Cancer Institute (NCI) 2008-10-31
NCT00362570 Temozolomide in Patients With Newly Diagnosed Anaplastic Oligodendroglioma and Mixed Oligoastrocytoma https://ClinicalTrials.gov/show/NCT00362570 Completed Ohio State University Comprehensive Cancer Center 2007-04-30
NCT00335075 Efficacy and Safety of Temodal vs Semustine in Subjects With Recurrent Glioblastoma or Anaplastic Astrocytoma (Study P03644) https://ClinicalTrials.gov/show/NCT00335075 Completed Merck Sharp & Dohme Corp. 2006-02-23
NCT00326664 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors https://ClinicalTrials.gov/show/NCT00326664 Completed National Cancer Institute (NCI) 2015-07-31
NCT00301418 Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma https://ClinicalTrials.gov/show/NCT00301418 Completed Northwell Health 2014-05-31
NCT00268385 Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas https://ClinicalTrials.gov/show/NCT00268385 Active, not recruiting National Cancer Institute (NCI) 2011-10-15
NCT00165360 Prolonged Daily Temozolomide for Low-Grade Glioma https://ClinicalTrials.gov/show/NCT00165360 Completed Dana-Farber Cancer Institute 2006-12-31
NCT00154375 Study of Imatinib Mesylate in Combination With Hydroxyurea Versus Hydroxyurea Alone as an Oral Therapy in Patients With Temozolomide Resistant Progressive Glioblastoma https://ClinicalTrials.gov/show/NCT00154375 Completed Novartis 2008-08-31
NCT00115440 BNCT to Treat Glioma That Has Progressed Following Radiotherapy https://ClinicalTrials.gov/show/NCT00115440 Completed Boneca Corporation 2008-12-31
NCT00101270 Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas https://ClinicalTrials.gov/show/NCT00101270 Completed National Cancer Institute (NCI) 2007-09-30
NCT00100880 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors https://ClinicalTrials.gov/show/NCT00100880 Completed National Cancer Institute (NCI) 2010-11-30
NCT00095940 Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors https://ClinicalTrials.gov/show/NCT00095940 Completed National Cancer Institute (NCI) 2010-07-31
NCT00093613 Sorafenib in Treating Patients With Recurrent or Progressive Malignant Glioma https://ClinicalTrials.gov/show/NCT00093613 Completed National Cancer Institute (NCI) 2010-10-31
NCT00003775 Leflunomide in Treating Patients With Anaplastic Astrocytoma in First Relapse https://ClinicalTrials.gov/show/NCT00003775 Completed Pfizer 2006-05-31
NCT00091182 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment https://ClinicalTrials.gov/show/NCT00091182 Completed National Cancer Institute (NCI) 2006-02-28
NCT00089427 IL13-PE38QQR Infusion After Tumor Resection, Followed by Radiation Therapy With or Without Temozolomide in Patients With Newly Diagnosed Malignant Glioma https://ClinicalTrials.gov/show/NCT00089427 Completed INSYS Therapeutics Inc 2007-07-31
NCT00085540 FR901228 in Treating Patients With Recurrent High-Grade Gliomas https://ClinicalTrials.gov/show/NCT00085540 Completed National Cancer Institute (NCI) 2008-12-31
NCT00003621 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Anaplastic Astrocytoma https://ClinicalTrials.gov/show/NCT00003621 Completed Alliance for Clinical Trials in Oncology 2005-02-28
NCT00002463 Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors https://ClinicalTrials.gov/show/NCT00002463 Completed M.D. Anderson Cancer Center 2007-01-31
NCT00080054 A Study of Motexafin Gadolinium and Temozolomide for the Treatment of Malignant Gliomas https://ClinicalTrials.gov/show/NCT00080054 Completed Pharmacyclics LLC. NA
NCT00077454 Erlotinib and Temozolomide in Treating Young Patients With Recurrent or Refractory Solid Tumors https://ClinicalTrials.gov/show/NCT00077454 Completed National Cancer Institute (NCI) 2007-09-30
NCT00064779 Imaging Study of the Distribution of IL13-PE38QQR Infused Before and After Surgery in Adult Patients With Recurrent Malignant Glioma https://ClinicalTrials.gov/show/NCT00064779 Completed INSYS Therapeutics Inc 2006-06-30
NCT00063973 Cilengitide in Treating Children With Refractory Primary Brain Tumors https://ClinicalTrials.gov/show/NCT00063973 Completed National Cancer Institute (NCI) 2008-03-31
NCT00004868 SU5416 in Treating Patients With Recurrent Astrocytoma or Mixed Glioma That Has Not Responded to Radiation Therapy https://ClinicalTrials.gov/show/NCT00004868 Completed Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2004-09-15
NCT00053963 FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia https://ClinicalTrials.gov/show/NCT00053963 Completed National Cancer Institute (NCI) 2006-02-28
NCT00004078 Irinotecan in Treating Children With Refractory Solid Tumors https://ClinicalTrials.gov/show/NCT00004078 Completed Children’s Oncology Group 2007-10-31
NCT00052780 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors https://ClinicalTrials.gov/show/NCT00052780 Completed National Cancer Institute (NCI) 2007-11-30
NCT00045708 A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas https://ClinicalTrials.gov/show/NCT00045708 Completed National Cancer Institute (NCI) 2010-05-31
NCT00045110 Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma https://ClinicalTrials.gov/show/NCT00045110 Completed National Cancer Institute (NCI) 2010-12-31
NCT00030498 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction https://ClinicalTrials.gov/show/NCT00030498 Completed National Cancer Institute (NCI) 2007-07-31
NCT00025675 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors https://ClinicalTrials.gov/show/NCT00025675 Completed Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2006-07-05
NCT00012181 Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas https://ClinicalTrials.gov/show/NCT00012181 Completed National Cancer Institute (NCI) 2005-01-31
NCT00004259 Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas https://ClinicalTrials.gov/show/NCT00004259 Completed Radiation Therapy Oncology Group 2015-02-01
NCT00004024 Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma https://ClinicalTrials.gov/show/NCT00004024 Completed Barbara Ann Karmanos Cancer Institute 2004-01-31
NCT00004017 Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma https://ClinicalTrials.gov/show/NCT00004017 Completed National Cancer Institute (NCI) NA
NCT00003537 Antineoplaston Therapy in Treating Adult Patients With Anaplastic Astrocytoma https://ClinicalTrials.gov/show/NCT00003537 Completed Burzynski Research Institute 2008-10-31
NCT00003470 Antineoplaston Therapy in Treating Patients With Anaplastic Astrocytoma https://ClinicalTrials.gov/show/NCT00003470 Completed Burzynski Research Institute 2008-12-31
NCT00003468 Antineoplaston Therapy in Treating Children With Low-Grade Astrocytoma https://ClinicalTrials.gov/show/NCT00003468 Completed Burzynski Research Institute 2004-07-31
NCT00002944 Combination Chemotherapy in Treating Children With Progressive Brain Tumors https://ClinicalTrials.gov/show/NCT00002944 Completed Children’s Oncology Group 2006-02-28
NCT00041587 Pre-operative IL13-PE38QQR in Patients With Recurrent or Progressive Malignant Glioma https://ClinicalTrials.gov/show/NCT00041587 Completed INSYS Therapeutics Inc 2006-06-30
NCT00795457 Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Adults With High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomas https://ClinicalTrials.gov/show/NCT00795457 Completed University of Pittsburgh 2013-02-28
NCT00028158 Safety and Effectiveness Study of G207, a Tumor-Killing Virus, in Patients With Recurrent Brain Cancer https://ClinicalTrials.gov/show/NCT00028158 Completed MediGene NA
NCT00112736 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma https://ClinicalTrials.gov/show/NCT00112736 Completed National Cancer Institute (NCI) 2010-04-30
NCT00028795 Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma https://ClinicalTrials.gov/show/NCT00028795 Completed Children’s Oncology Group 2007-09-30
NCT00024570 Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma https://ClinicalTrials.gov/show/NCT00024570 Completed INSYS Therapeutics Inc 2007-07-31
NCT00024557 Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients https://ClinicalTrials.gov/show/NCT00024557 Completed INSYS Therapeutics Inc 2006-06-30
NCT00042991 Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas https://ClinicalTrials.gov/show/NCT00042991 Completed National Cancer Institute (NCI) 2010-02-28
NCT00008008 Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma https://ClinicalTrials.gov/show/NCT00008008 Completed National Cancer Institute (NCI) 2005-06-30
NCT00070525 Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma https://ClinicalTrials.gov/show/NCT00070525 Completed National Cancer Institute (NCI) 2006-09-30
NCT00004688 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms https://ClinicalTrials.gov/show/NCT00004688 Completed FDA Office of Orphan Products Development NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT02747407 Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain Tumors https://ClinicalTrials.gov/show/NCT02747407 Active, not recruiting Wake Forest University Health Sciences 2019-04-17
NCT02731521 Clinical Development of MR Spectroscopy and Imaging in Brain Cancers https://ClinicalTrials.gov/show/NCT02731521 Recruiting University of Texas Southwestern Medical Center 2020-12-31
NCT02666066 Radiomics for Prediction of Survival in GBM https://ClinicalTrials.gov/show/NCT02666066 Completed Maastricht Radiation Oncology 2018-01-31
NCT02654340 Biomarkers for Tuberous Sclerosis Complex (BioTuScCom) https://ClinicalTrials.gov/show/NCT02654340 Recruiting Centogene AG Rostock 2023-12-30
NCT02388659 Clinical Development of Cancer-Specific MRS Biomarkers in Malignant Gliomas https://ClinicalTrials.gov/show/NCT02388659 Recruiting University of Texas Southwestern Medical Center 2020-12-31
NCT01417507 Natural History of Brain Function, Quality of Life, and Seizure Control in Patients With Brain Tumor Who Have Undergone Surgery https://ClinicalTrials.gov/show/NCT01417507 Completed Radiation Therapy Oncology Group 2014-12-31
NCT04304300 Radiotherapy in IDH Mutated Glioma: Evaluation of Late Outcomes https://ClinicalTrials.gov/show/NCT04304300 Recruiting Erasmus Medical Center 2024-05-31
NCT04211974 Genomic Landscape of Intramedullary Astrocytoma https://ClinicalTrials.gov/show/NCT04211974 Recruiting Xuanwu Hospital, Beijing 2022-12-10
NCT03900689 Social Determinants of Health in Glioblastoma Population https://ClinicalTrials.gov/show/NCT03900689 Recruiting Wake Forest University Health Sciences 2021-05-31
NCT03593993 A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas https://ClinicalTrials.gov/show/NCT03593993 Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2021-05-19
NCT02022384 Immunophenotyping From Blood of Patients With Malignant Gliomas https://ClinicalTrials.gov/show/NCT02022384 Recruiting University of Erlangen-Nürnberg Medical School 2020-12-31
NCT00999622 Study of Blood Samples and Risk of Infection in Patients With Newly Diagnosed Malignant Supratentorial Astrocytoma https://ClinicalTrials.gov/show/NCT00999622 Completed Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2009-08-31
NCT00919750 Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors https://ClinicalTrials.gov/show/NCT00919750 Completed Children’s Oncology Group 2018-06-30
NCT00898755 Collecting and Storing Tissue From Young Patients With Cancer https://ClinicalTrials.gov/show/NCT00898755 Completed Children’s Oncology Group 2008-07-17
NCT01849952 Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas https://ClinicalTrials.gov/show/NCT01849952 Recruiting Dartmouth-Hitchcock Medical Center 2022-05-31
NCT00723827 Temodal (Temozolomide) Post Marketing Surveillance Protocol (Study P05557AM2) https://ClinicalTrials.gov/show/NCT00723827 Completed Merck Sharp & Dohme Corp. 2011-09-30
NCT00705198 Temozolomide All-Case-Registered Surveillance (Designated Drug Use Investigation)(Study P05062) https://ClinicalTrials.gov/show/NCT00705198 Completed Merck Sharp & Dohme Corp. 2016-07-31
NCT00009035 Natural History of Patients With Brain and Spinal Cord Tumors https://ClinicalTrials.gov/show/NCT00009035 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001148 Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor https://ClinicalTrials.gov/show/NCT00001148 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03561207 3D Prediction of Patient-Specific Response https://ClinicalTrials.gov/show/NCT03561207 Recruiting KIYATEC 2024-06-30